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Early perturbations in keratin and actin gene expression and fibrillar organisation in griseofulvin-fed mouse liver

Journal of Hepatology, ISSN: 0168-8278, Vol: 33, Issue: 2, Page: 199-207
2000
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Article Description

Background/Aims: Long-term feeding of mice with a diet containing griseofulvin results in the formation of Mallory bodies, keratin K8 and K18 containing aggregates in hepatocytes. These bodies are biochemically and morphologically identical to the Mallory bodies that emerge in several human liver disorders. The aim of this study was to examine the contribution of K8 and K18 and actin to Mallory body formation.

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