Splanchnic and systemic hemodynamics in early abstinence and after ethanol administration in non-cirrhotic alcoholic patients
Journal of Hepatology, ISSN: 0168-8278, Vol: 20, Issue: 4, Page: 494-499
1994
- 19Citations
- 8Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations19
- Citation Indexes19
- 19
- CrossRef11
- Captures8
- Readers8
Article Description
Thirteen asymptomatic chronic alcoholic patients were studied to investigate the early stages of portal hypertension in alcoholic liver disease and the effects of withdrawal and ethanol on hepatic function and hemodynamic variables. None of the patients presented clinical signs of decompensated liver disease, and their liver biopsies showed normal liver or moderate alterations only. In basal conditions and after an intravenous ethanol infusion (1 g/kg body weight), hepatic venous pressure gradient and hepatic blood flow using indocyanine green were measured through hepatic vein catheterization. Hepatic sinusoidal vascular resistance and indocyanine green intrinsic clearance were also calculated. Portal blood flow measurements were obtained by Doppler ultrasound. No correlation was observed between hepatic venous pressure gradient and histologic features, (steatosis, necrosis, fibrosis, inflammation and hepatocyte surface area). In basal conditions, portal hypertension was not found in any case. After ethanol, portal pressure increased significantly ( p <0.001); in four cases it rose to or above 5 mmHg. Portal blood flow, hepatic blood flow and hepatic vascular resistance also increased significantly. Intrinsic indocyanine green clearance decreased slightly but significantly. No significant correlations were found between portal pressure, hepatic resistance and the histologic parameters. It was concluded that alcoholic patients, without clinical or laboratory evidence of liver failure and with minimal or moderate histologic alterations, have normal portal pressures. After an intravenous ethanol load, however, four out of 13 patients (31%) reached levels of 5 mmHg or more, irrespective of their liver histology.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0168827805804969; http://dx.doi.org/10.1016/s0168-8278(05)80496-9; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0028210791&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/8051388; http://linkinghub.elsevier.com/retrieve/pii/S0168827805804969; http://api.elsevier.com/content/article/PII:S0168827805804969?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:S0168827805804969?httpAccept=text/plain; https://linkinghub.elsevier.com/retrieve/pii/S0168827805804969; http://dx.doi.org/10.1016/s0168-8278%2805%2980496-9; https://dx.doi.org/10.1016/s0168-8278%2805%2980496-9
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