Characterization of a functional AT 1A angiotensin receptor in pancreatoma AR4–2J cells☆
Peptides, ISSN: 0196-9781, Vol: 20, Issue: 7, Page: 829-836
1999
- 12Citations
- 5Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations12
- Citation Indexes12
- 12
- CrossRef11
- Captures5
- Readers5
Article Description
Functional angiotensin receptors were characterized in the rat pancreatic acinar cell line AR4–2J. Angiotensin II stimulated a dose-dependent release of amylase and production of inositol phosphates. Results of high-performance liquid chromatography separation of inositol phosphates indicated that angiotensin stimulated the rapid accumulation of inositol 1,3,4-trisphosphate. Angiotensin II and angiotensin III were at least an order of magnitude more potent than angiotensin I in the stimulation of amylase release. The angiotensin II-stimulated amylase release was blocked by losartan, a selective AT 1 angiotensin antagonist. The selective AT 2 angiotensin receptor ligands CGP42112 did not alter angiotensin II-stimulated amylase released. However, CGP42112 stimulated amylase release at micromolar concentrations with a potency similar to angiotensin I. Analysis of mRNA expression by reverse transcription polymerase chain reaction suggested that AT 1A was the predominant type-I angiotensin receptor expressed in the AR4–2J cells.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0196978199000698; http://dx.doi.org/10.1016/s0196-9781(99)00069-8; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0032587054&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/10477083; https://linkinghub.elsevier.com/retrieve/pii/S0196978199000698; http://linkinghub.elsevier.com/retrieve/pii/S0196978199000698; http://api.elsevier.com/content/article/PII:S0196978199000698?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:S0196978199000698?httpAccept=text/plain; http://dx.doi.org/10.1016/s0196-9781%2899%2900069-8; https://dx.doi.org/10.1016/s0196-9781%2899%2900069-8
Elsevier BV
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