Regulation of gene expression by natural antisense RNA transcripts
Neurochemistry International, ISSN: 0197-0186, Vol: 31, Issue: 3, Page: 379-392
1997
- 107Citations
- 44Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations107
- Citation Indexes107
- 107
- CrossRef73
- Captures44
- Readers44
- 44
Article Description
The use of synthetic antisense oligonucleotides as specific inhibitors of gene expression exploits the susceptibility of mRNA to functional blockade at several levels, including mRNA processing, transport, translation and degradation. It is becoming increasingly apparent that the actions of these synthetic oligomers are analogous to those of endogenous RNA molecules involved in the regulation of gene expression in both prokaryotes and eukaryotes. A growing number of eukaryotic genes are now thought to be regulated at least in part by natural antisense RNA transcribed from the presumptive non-coding DNA strand. This possibility is supported by the presence of a complex system of double-stranded (ds) RNA-specific proteins and dsRNA-induced signal transduction pathways in eukaryotic cells. The presence of functional open reading frames in a number of recognized natural antisense RNA transcripts indicates that, in addition to regulating gene function at the RNA level, the antisense strand of many genes may code for as yet unidentified proteins. In the present study we review the current literature on the role(s) played by natural antisense RNA in eukaryotic cells, with an emphasis on genes for which clear evidence of regulation, or potential regulation by natural antisense RNA is available.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0197018696001088; http://dx.doi.org/10.1016/s0197-0186(96)00108-8; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0030757318&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/9246680; http://linkinghub.elsevier.com/retrieve/pii/S0197018696001088; http://api.elsevier.com/content/article/PII:S0197018696001088?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:S0197018696001088?httpAccept=text/plain; https://linkinghub.elsevier.com/retrieve/pii/S0197018696001088; http://dx.doi.org/10.1016/s0197-0186%2896%2900108-8; https://dx.doi.org/10.1016/s0197-0186%2896%2900108-8
Elsevier BV
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know