Genetic association between interleukin-10 gene promoter region polymorphisms and type 1 diabetes age-at-onset
Human Immunology, ISSN: 0198-8859, Vol: 63, Issue: 8, Page: 690-695
2002
- 53Citations
- 17Captures
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Metrics Details
- Citations53
- Citation Indexes53
- 53
- CrossRef43
- Captures17
- Readers17
- 17
Article Description
This study investigated whether interleukin-10 (IL-10) gene promoter region polymorphisms are associated with susceptibility to or clinical presentation of type 1 diabetes. The frequency of -1082G/A, -819C/T, and -592C/A polymorphisms was analyzed in 128 Japanese patients with type 1 diabetes and in 107 healthy control subjects in a case-controlled study. The allelic and haplotypic frequencies of the IL-10 gene promoter region polymorphisms were similar in patients with type 1 diabetes and in control subjects. However, the -819T and -592A allele were associated with adult-onset (>18 years) of the disease ( p = 0.037). Furthermore, the frequency of ATA haplotype was increased in adult-onset patients than that in early-onset patients (≤18 years; p = 0.037). Among the genotypes comprising ATA haplotype, the frequency of ATA/ATA was significantly higher in adult-onset patients than in early-onset patients ( p = 0.004). These results suggest that the IL-10 gene promoter polymorphisms are associated with the age-at-onset in Japanese patients with type 1 diabetes.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0198885902004172; http://dx.doi.org/10.1016/s0198-8859(02)00417-2; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0036020525&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/12121678; https://linkinghub.elsevier.com/retrieve/pii/S0198885902004172; http://linkinghub.elsevier.com/retrieve/pii/S0198885902004172; http://api.elsevier.com/content/article/PII:S0198885902004172?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:S0198885902004172?httpAccept=text/plain; http://dx.doi.org/10.1016/s0198-8859%2802%2900417-2; https://dx.doi.org/10.1016/s0198-8859%2802%2900417-2
Elsevier BV
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