Oral vaccination with Mycobacterium bovis BCG in a lipid formulation induces resistance to pulmonary tuberculosis in brushtail possums
Vaccine, ISSN: 0264-410X, Vol: 22, Issue: 1, Page: 70-76
2003
- 105Citations
- 86Captures
- 1Mentions
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Metrics Details
- Citations105
- Citation Indexes103
- 103
- CrossRef89
- Policy Citations2
- Policy Citation2
- Captures86
- Readers86
- 86
- Mentions1
- Blog Mentions1
- Blog1
Most Recent Blog
The Effect of Oral Vaccination with Mycobacterium bovis BCG on the Development of Tuberculosis in Captive European Badgers (Meles meles)
Introduction Reducing the prevalence of TB in badgers through vaccination, and as a consequence reducing the risk of transmission of infection to and from cattle, is part of the long-term plan to eradicate TB from cattle in the UK and Ireland. The costs associated with its purchase and the costs and practical limitations associated with its administration limit its use in the field (Enticott et al
Article Description
A method was developed for formulating Mycobacterium bovis bacille Calmette–Guerin (BCG) for oral vaccination against tuberculosis. Selected lipid-based formulations of BCG were tested in the brushtail possum for their ability to elicit immune responses and protection against bovine tuberculosis. Formulation of BCG in lipid matrices maintained bacteria in a dormant but viable state. Oral delivery of 2×10 8 colony forming units of formulated BCG to possums induced strong lymphocyte proliferation responses to bovine purified protein derivative (PPD) in peripheral blood lymphocytes. Oral vaccination of possums also reduced the severity of disease following aerosol challenge with virulent M. bovis compared with animals vaccinated with non-formulated BCG. In a second experiment, levels of protection with lipid-formulated oral BCG were similar to those seen with subcutaneous BCG vaccination. Our data shows that formulated oral BCG is an efficient means of inducing protection against bovine tuberculosis in possums and should be a practical means of vaccinating wildlife against tuberculosis.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0264410X03005395; http://dx.doi.org/10.1016/s0264-410x(03)00539-5; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0242352546&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/14604573; http://linkinghub.elsevier.com/retrieve/pii/S0264410X03005395; http://api.elsevier.com/content/article/PII:S0264410X03005395?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:S0264410X03005395?httpAccept=text/plain; https://linkinghub.elsevier.com/retrieve/pii/S0264410X03005395; http://dx.doi.org/10.1016/s0264-410x%2803%2900539-5; https://dx.doi.org/10.1016/s0264-410x%2803%2900539-5
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