Immunoglobulin-Antiimmunoglobulin Interactions and Immune Complexes in IgA Nephropathy
American Journal of Kidney Diseases, ISSN: 0272-6386, Vol: 12, Issue: 5, Page: 425-429
1988
- 24Citations
- 3Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations24
- Citation Indexes24
- 24
- CrossRef19
- Captures3
- Readers3
Article Description
IgA nephropathy (IgAN) is characterized by mesangial co-deposition of IgA and C3. Elevated levels of circulating immune complexes containing these components in significant numbers of patients have been found in several studies; IgAN is therefore assumed by many investigators to be an immune complex-mediated disease. Our studies have shown that IgG is often co-complexed with IgA within circulating immune complexes, and we have begun to examine the potential mechanisms for these observations. In this regard, elevated levels of IgA rheumatoid factor and of IgG anti-IgA antibodies were found in some patients. Nevertheless, we were unable to correlate levels of circulating immune complexes with any clinical index of disease. Furthermore, many individuals with the acquired immune deficiency syndrome (AIDS) also have elevated levels of circulating immune complexes containing IgG and IgA, IgA rheumatoid factor, and IgG anti-IgA antibodies, although these patients apparently do not have mesangial IgA deposits. Therefore, the role of circulating IgA-containing immune complexes in the pathogenesis of IgAN requires further evaluation.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0272638688800398; http://dx.doi.org/10.1016/s0272-6386(88)80039-8; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0023716130&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/3055969; http://linkinghub.elsevier.com/retrieve/pii/S0272638688800398; http://api.elsevier.com/content/article/PII:S0272638688800398?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:S0272638688800398?httpAccept=text/plain; https://linkinghub.elsevier.com/retrieve/pii/S0272638688800398; http://dx.doi.org/10.1016/s0272-6386%2888%2980039-8; https://dx.doi.org/10.1016/s0272-6386%2888%2980039-8
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