Peroxisome proliferator-activated receptor-α expressionin rat liver during postnatal development
Biochimie, ISSN: 0300-9084, Vol: 82, Issue: 8, Page: 723-726
2000
- 32Citations
- 12Captures
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Metrics Details
- Citations32
- Citation Indexes32
- 32
- CrossRef26
- Captures12
- Readers12
- 12
Article Description
The expression of the peroxisome proliferator-activated receptor-α (PPARα) as well as of some related genes was studied in rat liver at different stages of development (from 19-day-old fetuses to 1 month-old rats). The level of PPARα mRNA appeared higher in neonates than in fetuses or 1 month-old rats. Whereas the pattern for phosphoenolpyruvate carboxykinase (PEPCK) mRNA level was similar to that of PPARα, the mRNA level of both acyl-CoA oxidase (ACO) and apolipoprotein CIII (apo CIII) showed diverse profiles. Western blotting analysis also revealed an increased level of PPARα protein in liver of suckling rats. Similarities of mRNA PEPCK and PPARα expression indicate a common control mechanism, where both nutritional and hormonal factors may be involved.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0300908400011470; http://dx.doi.org/10.1016/s0300-9084(00)01147-0; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0033809315&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/11018288; http://linkinghub.elsevier.com/retrieve/pii/S0300908400011470; http://api.elsevier.com/content/article/PII:S0300908400011470?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:S0300908400011470?httpAccept=text/plain; https://linkinghub.elsevier.com/retrieve/pii/S0300908400011470; http://dx.doi.org/10.1016/s0300-9084%2800%2901147-0; https://dx.doi.org/10.1016/s0300-9084%2800%2901147-0
Elsevier BV
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