Signal Transduction Pathways for Serotonin as an Intestinal Secretagogue
Comparative Biochemistry and Physiology Part A: Physiology, ISSN: 0300-9629, Vol: 118, Issue: 2, Page: 283-290
1997
- 66Citations
- 15Captures
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Metrics Details
- Citations66
- Citation Indexes66
- 66
- CrossRef50
- Captures15
- Readers15
- 15
Article Description
This review presents a signal transduction pathways for serotonin (5-hydroxytryptamine, 5-HT) as an intestinal secretagogue and some recently published related findings. 5-HT is a secretagogue in the small and large intestine of all studied species including pig and man. 5-HT mediates intestinal secretion through activation of at least the epithelial 5-HT 2, and neuronal 5-HT 3, and 5-HT 4 receptors in the submucosal plexus, including a reflex arc. 5-HT activates both a cholinergic and a non-cholinergic pathway in its secretory response. Intracellular mediators include at least eicosanoids (prostaglandin E 2 ), calcium, phosphoinositols (1,4,5-inositol trisphosphate) and maybe nitric oxide and cyclic nucleotides. Pig small intestine appears to be an appropriate model for the human small intestine with respect to the signal transduction pathways for 5-HT as an intestinal secretagogue. Species and segmental differences in the signal transduction pathways for 5-HT as an intestinal secretagogues are discussed together with related news on 5-HT receptors, 5-HT antagonists in clinical use, the enteric nervous system, and intracellular mediators.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0300962997000856; http://dx.doi.org/10.1016/s0300-9629(97)00085-6; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0031260218&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/9366057; https://linkinghub.elsevier.com/retrieve/pii/S0300962997000856; http://linkinghub.elsevier.com/retrieve/pii/S0300962997000856; http://api.elsevier.com/content/article/PII:S0300962997000856?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:S0300962997000856?httpAccept=text/plain; http://dx.doi.org/10.1016/s0300-9629%2897%2900085-6; https://dx.doi.org/10.1016/s0300-9629%2897%2900085-6
Elsevier BV
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