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Effects of noise on the off rate of Ca 2+ binding proteins in a coupled biochemical cell system

Biophysical Chemistry, ISSN: 0301-4622, Vol: 94, Issue: 3, Page: 201-207
2001
  • 17
    Citations
  • 0
    Usage
  • 3
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    17
    • Citation Indexes
      17
  • Captures
    3

Article Description

We investigated numerically the kinetic properties of calcium binding proteins by using a three-calcium store model and discussed the response of a two-way coupled biochemical cell system, whose subsystems were coupled via diffusion-like cytosolic calcium transfer through gap junctions, to the external stimulation. When we used noise to modulate the off rate of the Ca 2+ binding proteins in simulation, an SR-like phenomenon of synchronous oscillations is observed. In addition, the interaction involving noise, coupling and the dynamics of Ca 2+ binding proteins is discussed.

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