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Polymorphism of the stress protein HSP70-2 gene is associated with the susceptibility to the nasopharyngeal carcinoma

Cancer Letters, ISSN: 0304-3835, Vol: 193, Issue: 1, Page: 75-81
2003
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Article Description

Several studies have shown statistical evidence of association between nasopharyngeal carcinoma (NPC) and specific human leukocyte antigen (HLA) alleles and highlighted the presence of candidate genes for this cancer within or nearby the HLA. Given their chromosomal location within HLA and their determining role in the immune response to tumor cells, we designed a case–controlled study to investigate the potential association of the genetic variation of the tumor necrosis factor-alpha (TNF-α) and that of the heat shock protein 70-2 (HSP70-2) with NPC.

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