Estrogenic and antiestrogenic regulation of MMP-2 and MMP-13 mRNA in RUCA-I endometrial tumor cells in vitro and in vivo
Cancer Letters, ISSN: 0304-3835, Vol: 198, Issue: 1, Page: 99-106
2003
- 10Citations
- 7Captures
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Metrics Details
- Citations10
- Citation Indexes10
- 10
- CrossRef7
- Captures7
- Readers7
Article Description
We investigated the influence of estrogenic and antiestrogenic treatment on proteolytic activity – especially on MMP-2 and MMP-13 – in the RUCA-I transplantable endometrial tumor model. Morphological studies demonstrate that RUCA-I cells are forming highly differentiated gland-like structures by remodelling and invading the underlying ECM. Estrogens upregulate the mRNA levels of MMP-2 and MMP-13 in the rat uterus. Treatment with the pure antiestrogen ICI 182,780 results in the downregulation of MMP-2 and MMP-13 mRNA. The same regulation for MMP-13 mRNA is found in vitro in RUCA-I cells. In contrast, in the transplantation tumor, the mRNA level of MMP-13 is repressed by estrogens and induced by ICI 182,780. MMP-2 mRNA is not regulated by hormones in the transplantation tumor and in RUCA-I cells. The divergent regulation suggests a varying influence of cell–cell-, cell–extracellular matrix interactions and soluble factors.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0304383503002751; http://dx.doi.org/10.1016/s0304-3835(03)00275-1; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0142026844&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/12893436; https://linkinghub.elsevier.com/retrieve/pii/S0304383503002751; http://linkinghub.elsevier.com/retrieve/pii/S0304383503002751; http://api.elsevier.com/content/article/PII:S0304383503002751?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:S0304383503002751?httpAccept=text/plain; http://dx.doi.org/10.1016/s0304-3835%2803%2900275-1; https://dx.doi.org/10.1016/s0304-3835%2803%2900275-1
Elsevier BV
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