Protein turnover in skeletal muscle of tumour-bearing transgenic mice overexpressing the soluble TNF receptor-1
Cancer Letters, ISSN: 0304-3835, Vol: 130, Issue: 1, Page: 19-27
1998
- 71Citations
- 40Captures
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Metrics Details
- Citations71
- Citation Indexes71
- 71
- CrossRef57
- Captures40
- Readers40
- 40
Article Description
The implantation of the Lewis lung carcinoma (a fast-growing mouse tumour that induces cachexia) to both wild-type and transgenic mice for the soluble TNF receptor type I protein (sTNF-R1) resulted in a considerable loss of carcass weight in both groups. However, while in the wild-type mice there was a loss of both fat and muscle, in the transgenic mice muscle waste was not affected to the same extent as in the wild-type group. Muscle waste in wild-type mice was accompanied by an increase in the fractional rate of protein degradation, while no changes were observed in protein synthesis. The result was a decreased rate of protein accumulation which accounted for the muscle weight loss observed as a result of the tumour burden. In contrast, transgenic mice did not have such low rates of protein accumulation after tumour implantation. The increase in protein degradation in the tumour-bearing transgenic mice was accompanied by a similar increase in protein synthesis which compensated for the loss of muscle protein by degradation. Both tumour-bearing groups showed an enhanced expression of ubiquitin and proteasome C8 subunit genes, all of them related to the activation of the ATP-dependent proteolytic system in skeletal muscle. It is suggested that TNF may, in part, be responsible for the loss of protein in skeletal muscle of tumour-bearing mice.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0304383598001372; http://dx.doi.org/10.1016/s0304-3835(98)00137-2; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0032516677&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/9751252; https://linkinghub.elsevier.com/retrieve/pii/S0304383598001372; http://linkinghub.elsevier.com/retrieve/pii/S0304383598001372; http://api.elsevier.com/content/article/PII:S0304383598001372?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:S0304383598001372?httpAccept=text/plain; http://dx.doi.org/10.1016/s0304-3835%2898%2900137-2; https://dx.doi.org/10.1016/s0304-3835%2898%2900137-2
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