Upregulation of neuronal nitric oxide synthase, edema and cell injury following heat stress are reduced by pretreatment with EGB-761 in the rat
Journal of Thermal Biology, ISSN: 0306-4565, Vol: 24, Issue: 5, Page: 439-445
1999
- 16Citations
- 2Captures
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Article Description
Rats exposed to 4 h heat stress (HS) at 38°C exhibited marked upregulation of neuronal nitric oxide synthase (nNOS) in the brain regions exhibiting blood–brain barrier (BBB) breakdown, brain edema and cell damage. Pretreatment with an anti-oxidant compound EGB-761 (an extract of Gingko biloba ) administered 50 mg/kg, per os for 5 days, significantly attenuated nNOS expression, BBB disruption, brain edema and cell injury. These results suggest that EGB-761 is neuroprotective in heat stress and this effect of the compound is related with the inhibition of NOS expression, not reported earlier.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0306456599000807; http://dx.doi.org/10.1016/s0306-4565(99)00080-7; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0033389251&origin=inward; https://linkinghub.elsevier.com/retrieve/pii/S0306456599000807; https://api.elsevier.com/content/article/PII:S0306456599000807?httpAccept=text/xml; https://api.elsevier.com/content/article/PII:S0306456599000807?httpAccept=text/plain; http://dx.doi.org/10.1016/s0306-4565%2899%2900080-7; https://dx.doi.org/10.1016/s0306-4565%2899%2900080-7
Elsevier BV
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