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Poly- l -glutamic acid and poly- l -lysine: model substances for studying secondary structures of proteins

Biochemistry and Molecular Biology Education, ISSN: 1470-8175, Vol: 28, Issue: 5, Page: 244-247
2000
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Poly- l -glutamic acid (PGA) and poly- l -lysine (PL) and related polymers have played a central role in investigations of the physical chemistry of chain molecules. PGA and PL are synthetic polypeptides which are especially good models for studying formation and/or disappearance of α -helix. A theoretical and laboratory practical exercise is proposed in order to illustrate the influence of pH and solvent on conformation of these polypeptides.

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