Increased dopamine D2 receptor binding and enhanced apomorphine-induced locomotor activity in μ-opioid receptor knockout mice
Brain Research Bulletin, ISSN: 0361-9230, Vol: 61, Issue: 1, Page: 109-115
2003
- 32Citations
- 12Captures
Metric Options: Counts1 Year3 YearSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations32
- Citation Indexes32
- 32
- CrossRef29
- Captures12
- Readers12
- 12
Article Description
Previous studies from our laboratory have indicated possible interactions between opioidergic and dopaminergic neurons in the central nervous system. In this study, apomorphine-induced locomotor activity and the D1 and D2 subtype dopamine receptor binding were examined in mice lacking the μ-opioid receptor genes. The ambulatory time, vertical time and total motor distance of locomotor activity were measured after administration of apomorphine (2 mg/kg, i.p.) for a period of 90 min. The autoradiographic studies of D1 and D2 dopamine receptors were conducted using [ 3H ] SCH23390 and [ 3H ] raclopride as ligand, respectively. In wild type mice that received apomorphine, 2 mg/kg, i.p., the locomotor activity such as ambulatory time, vertical time and total motor distance were not significantly altered as compared with that of the saline control group. However, the locomotor activity measured was significantly increased in the same dose of apomorphine treated μ-opioid receptor knockout mice between 5 and 40 min after administration. The results obtained also show that the binding of D2 dopamine receptor in μ-opioid receptor knockout mice was significantly higher than that of the wild type in the caudate putamen. However, the binding of the D1 dopamine receptor in μ-opioid receptor knockout mice was not significantly different from that of the wild type. It appears that the apomorphine treated μ-opioid receptor knockout mice showed enhancement in locomotor activity. The enhanced locomotor activity may be related to the compensatory up-regulation of D2 dopamine receptors in mice lacking μ-opioid receptor genes.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0361923003000777; http://dx.doi.org/10.1016/s0361-9230(03)00077-7; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0037872140&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/12788214; http://linkinghub.elsevier.com/retrieve/pii/S0361923003000777; http://api.elsevier.com/content/article/PII:S0361923003000777?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:S0361923003000777?httpAccept=text/plain; https://linkinghub.elsevier.com/retrieve/pii/S0361923003000777; http://dx.doi.org/10.1016/s0361-9230%2803%2900077-7; https://dx.doi.org/10.1016/s0361-9230%2803%2900077-7
Elsevier BV
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know