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RXR-2 , a member of the retinoid x receptor family in Schistosoma mansoni

Gene, ISSN: 0378-1119, Vol: 233, Issue: 1, Page: 33-38
1999
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Article Description

A cDNA encoding a second full-length member of the Schistosoma mansoni RXR family ( SmRXR-2 ) was identified. The nucleotide sequence of SmRXR-2 translates into a protein of 784 amino acids with a p I of 7.63 and an approximate mass of 78 kDa making it the largest reported RXR to date. Phylogenetic tree analysis provides evidence that SmRXR-2 is the most ancient full-length RXR identified. SmRXR-2 exhibits unique sequence features compared with other RXRs. RT-PCR results demonstrate that the SmRXR-2 gene is constitutively expressed and thus must play multiple roles throughout schistosome development in the vertebrate host.

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