Lecithin microemulsions for the topical administration of ketoprofen: percutaneous adsorption through human skin and in vivo human skin tolerability
International Journal of Pharmaceutics, ISSN: 0378-5173, Vol: 244, Issue: 1, Page: 21-31
2002
- 195Citations
- 108Captures
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Metrics Details
- Citations195
- Citation Indexes195
- 195
- CrossRef105
- Captures108
- Readers108
- 108
Article Description
The potential application of highly biocompatible o/w microemulsions as topical drug carrier systems for the percutaneous delivery of anti-inflammatory drugs, i.e. ketoprofen, was investigated. Microemulsions were made up of triglycerides as oil phase, a mixture of lecithin and n -butanol as a surfactant/co-surfactant system and an aqueous solution as the external phase. To evaluate the percutaneous enhancing effect of oleic acid, this compound was used as a component of some o/w microemulsions. The topical carrier potentialities of lecithin-based o/w microemulsions were compared with respect to conventional formulations, i.e. a w/o emulsion, a o/w emulsion and a gel. Physicochemical characterisation of microemulsions was carried out by light scattering and zeta potential analyses. Microemulsions showed mean droplet size <35 nm and a negative zeta potential, that is −39.5 mV for the oleic acid–lecithin microemulsion and −19.7 mV for the lecithin-based microemulsion. The percutaneous adsorption of the various topical formulations was evaluated through healthy adult human skin, which was obtained from abdominal reduction surgery. Ketoprofen-loaded microemulsions showed an enhanced permeation through human skin with respect to conventional formulations. No significant percutaneous enhancer effect was observed for ketoprofen-loaded oleic acid–lecithin microemulsions. The human skin tolerability of various microemulsion formulations was evaluated on human volunteers. Microemulsions showed a good human skin tolerability.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0378517302002958; http://dx.doi.org/10.1016/s0378-5173(02)00295-8; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0037026275&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/12204562; https://linkinghub.elsevier.com/retrieve/pii/S0378517302002958; http://linkinghub.elsevier.com/retrieve/pii/S0378517302002958; http://api.elsevier.com/content/article/PII:S0378517302002958?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:S0378517302002958?httpAccept=text/plain; http://dx.doi.org/10.1016/s0378-5173%2802%2900295-8; https://dx.doi.org/10.1016/s0378-5173%2802%2900295-8
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