The effect of combined administration of cadmium and furosemide on auditory function in the rat
Hearing Research, ISSN: 0378-5955, Vol: 129, Issue: 1, Page: 61-70
1999
- 26Citations
- 22Captures
Metric Options: Counts1 Year3 YearSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations26
- Citation Indexes25
- 25
- CrossRef17
- Policy Citations1
- Policy Citation1
- Captures22
- Readers22
- 22
Article Description
A number of heavy metals have been associated with toxic effects to the peripheral or central auditory system. These include lead, arsenic, mercury, platinum and organic tin compounds. In addition, the ototoxic effects of some metals may be potentiated by other factors. However, the auditory effects of cadmium have not previously been reported. The purpose of the present study was to investigate the potential ototoxic effects of cadmium from an acute dosage, and its potentiation by furosemide. Auditory brainstem response (ABR) thresholds were measured in adult Sprague-Dawley rats. Rats received either cadmium chloride (5 mg/kg, i.p.) followed by saline (4 ml/kg, i.p.), cadmium chloride followed by furosemide (200 mg/kg, i.p.), or furosemide alone. Follow-up ABRs were carried out 7 days post-treatment and threshold changes were compared between each treatment group. No significant threshold change was seen for the cadmium chloride plus saline treated or the furosemide treated animals. However, significant threshold elevations were observed in animals receiving cadmium chloride plus furosemide. In addition, scanning electron microscopy revealed extensive hair cell loss in animals treated with cadmium chloride and furosemide. Although functional auditory changes were not seen after the administration of cadmium alone, the potentiation of threshold changes by furosemide suggests that cadmium may be ototoxic under certain conditions.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0378595598002226; http://dx.doi.org/10.1016/s0378-5955(98)00222-6; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0032987878&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/10190752; https://linkinghub.elsevier.com/retrieve/pii/S0378595598002226; http://linkinghub.elsevier.com/retrieve/pii/S0378595598002226; http://api.elsevier.com/content/article/PII:S0378595598002226?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:S0378595598002226?httpAccept=text/plain; http://dx.doi.org/10.1016/s0378-5955%2898%2900222-6; https://dx.doi.org/10.1016/s0378-5955%2898%2900222-6
Elsevier BV
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know