Apoptosis induced in small intestinal crypts by low doses of radiation protects the epithelium from genotoxic damage
International Congress Series, ISSN: 0531-5131, Vol: 1236, Issue: C, Page: 407-413
2002
- 2Citations
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Article Description
The ultimate stem cells in the small intestinal crypts divide about 1000 times in the lifetime of a mouse and through a series of transit dependent dividing cell generations produce about 2.5×10 11 intestinal epithelial cells in the 3-year life span. In spite of the large number of stem cells in the small intestine and their rapid and extensive cell cycles, genetic defects leading to cancer or age-related deterioration are rare, indicating that the cells are well protected against these changes. Here, discussed are three ways in which protection is afforded.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0531513101007695; http://dx.doi.org/10.1016/s0531-5131(01)00769-5; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84866505239&origin=inward; http://linkinghub.elsevier.com/retrieve/pii/S0531513101007695; http://api.elsevier.com/content/article/PII:S0531513101007695?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:S0531513101007695?httpAccept=text/plain; https://linkinghub.elsevier.com/retrieve/pii/S0531513101007695; https://api.elsevier.com/content/article/PII:S0531513101007695?httpAccept=text/xml; https://api.elsevier.com/content/article/PII:S0531513101007695?httpAccept=text/plain; http://dx.doi.org/10.1016/s0531-5131%2801%2900769-5; https://dx.doi.org/10.1016/s0531-5131%2801%2900769-5
Elsevier BV
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