Longevity, genes, and aging: a view provided by a genetic model system 1 1This article is based on the Nathan Shock Award Lecture given by the author at the Gerontology Research Center of the National Institute on Aging in Baltimore, MD (USA) in June, 1997.
Experimental Gerontology, ISSN: 0531-5565, Vol: 34, Issue: 1, Page: 1-6
1999
- 31Citations
- 34Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations31
- Citation Indexes31
- 31
- CrossRef20
- Captures34
- Readers34
- 33
Article Description
The genetic analysis of aging in the yeast Saccharomyces cerevisiae has revealed the importance of metabolic capacity, resistance to stress, integrity of gene regulation, and genetic stability for longevity. A balance between these life maintenance processes is sustained by the RAS2 gene, which channels cellular resources among them. This gene cooperates with mitochondria and PHB1 in metabolic adjustments important for longevity. It also modulates stress responses. Transcriptional silencing of heterochromatic regions of the genome is lost during aging, suggesting that gene dysregulation accompanies the aging process. There is evidence that this age change plays a causal role. Aging possesses features of a nonlinear process, and it is likely that application of nonlinear system methodology to aging will be productive.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0531556598000539; http://dx.doi.org/10.1016/s0531-5565(98)00053-9; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0033042359&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/10197723; http://linkinghub.elsevier.com/retrieve/pii/S0531556598000539; http://api.elsevier.com/content/article/PII:S0531556598000539?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:S0531556598000539?httpAccept=text/plain; https://linkinghub.elsevier.com/retrieve/pii/S0531556598000539; http://dx.doi.org/10.1016/s0531-5565%2898%2900053-9; https://dx.doi.org/10.1016/s0531-5565%2898%2900053-9
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