Assessment of ESR-CT imaging by comparison with autoradiography for the distribution of a blood-brain-barrier permeable spin probe, MC-PROXYL, to rodent brain
Magnetic Resonance Imaging, ISSN: 0730-725X, Vol: 21, Issue: 7, Page: 765-772
2003
- 47Citations
- 8Captures
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Metrics Details
- Citations47
- Citation Indexes47
- 47
- CrossRef44
- Captures8
- Readers8
Article Description
Blood-brain-barrier (BBB)-permeable, 3-methoxycarbonyl-2,2,5,5-tetramethylpyrrolidine-1-yloxy (MC-PROXYL) and BBB-impermeable carbamoyl-PROXYL were used to assess the ESR imaging technique by comparing with autoradiography. For this purpose, spin probes, 14 C-labeled at their five-membered ring, [ 14 C]MC-PROXYL and [ 14 C]carbamoyl-PROXYL, were newly synthesized. These probes were i.p. or i.v. injected into rats and autoradiograms were recorded. The autoradiograms of rat head showed that [ 14 C]MC-PROXYL distributed well in the brain compared to [ 14 C]carbamoyl-PROXYL. In vivo ESR spectra and two-dimensional ESR images of isolated rat brain treated with MC- or carbamoyl-PROXYL also indicated the extensive distribution of MC-PROXYL but not carbamoyl-PROXYL in the rat brain. The three-dimensional ESR images of the head of rats and mice were consistent with the fact that MC-PROXYL but not carbamoyl-PROXYL is incorporated into the brain. The ESR-CT images were better for mice than rats. However, the quality of the ESR-CT images was still not satisfactory. Although the resolution and sensitivity of the ESR-CT images were worse than those of the autoradiographic images, the former technique has unique features and advantages; e.g., functional, noninvasive and three-dimensional detection.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0730725X03001188; http://dx.doi.org/10.1016/s0730-725x(03)00118-8; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0041791182&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/14559341; http://linkinghub.elsevier.com/retrieve/pii/S0730725X03001188; http://api.elsevier.com/content/article/PII:S0730725X03001188?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:S0730725X03001188?httpAccept=text/plain; https://linkinghub.elsevier.com/retrieve/pii/S0730725X03001188; http://dx.doi.org/10.1016/s0730-725x%2803%2900118-8; https://dx.doi.org/10.1016/s0730-725x%2803%2900118-8
Elsevier BV
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