Total synthesis of human chymase inhibitor methyllinderone and structure–activity relationships of its derivatives
Bioorganic & Medicinal Chemistry Letters, ISSN: 0960-894X, Vol: 11, Issue: 13, Page: 1695-1697
2001
- 32Citations
- 6Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations32
- Citation Indexes32
- 32
- CrossRef27
- Captures6
- Readers6
Article Description
Total synthesis of human chymase inhibitor methyllinderone has been achieved in only four steps with an overall yield of 21% from dimethyl squarate. We developed an efficient synthetic method for obtaining methyllinderone derivatives and found the active compound. In addition, we propose the inhibition mechanism of the active compound against human chymase using calculations.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0960894X01002657; http://dx.doi.org/10.1016/s0960-894x(01)00265-7; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0035833029&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/11425540; https://linkinghub.elsevier.com/retrieve/pii/S0960894X01002657; http://linkinghub.elsevier.com/retrieve/pii/S0960894X01002657; http://api.elsevier.com/content/article/PII:S0960894X01002657?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:S0960894X01002657?httpAccept=text/plain; http://dx.doi.org/10.1016/s0960-894x%2801%2900265-7; https://dx.doi.org/10.1016/s0960-894x%2801%2900265-7
Elsevier BV
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