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Monocharged inhibitors of mast cell tryptase derived from potent and selective dibasic inhibitors

Bioorganic & Medicinal Chemistry Letters, ISSN: 0960-894X, Vol: 11, Issue: 17, Page: 2325-2330
2001
  • 17
    Citations
  • 0
    Usage
  • 4
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    17
    • Citation Indexes
      17
  • Captures
    4

Article Description

Truncation of potent and selective dibasic inhibitors afforded monocharged inhibitors of human mast-cell tryptase. Using two classes of analogues as lead structures, several monocharged derivatives were identified with K i values ranging from 0.084 to 0.21 μM against the enzyme.

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