PlumX Metrics
Embed PlumX Metrics

Synthesis and estrogen receptor binding affinities of 7-hydroxy-3-(4-hydroxyphenyl)-4 H -1-benzopyran-4-ones containing a basic side chain

Bioorganic & Medicinal Chemistry Letters, ISSN: 0960-894X, Vol: 13, Issue: 8, Page: 1475-1478
2003
  • 26
    Citations
  • 0
    Usage
  • 9
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

Article Description

Two isoflavones containing a sulfur or oxygen hinge with an amine-bearing side chain have been designed and synthesized as potential selective estrogen receptor modulators. The target compounds exhibited low affinities for estrogen receptors (ERs), and binding affinity data indicate that oxygen hinge is more favorable than sulfur for binding. These compounds also displayed selectivity for ERα over ERβ.

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know