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A novel metal-Chelating inhibitor of protein farnesyltransferase

Bioorganic & Medicinal Chemistry Letters, ISSN: 0960-894X, Vol: 13, Issue: 9, Page: 1523-1526
2003
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Article Description

A novel metal chelator comprising a 4-(naphthalen-1-yl)pyridine and 2-aminoethanethiol was synthesized. This showed inhibitory activity against human protein farnesyltransferase with IC 50 1.9 μM, induced morphological change in K-ras-NRK cells at 0.5 μg/mL and showed growth inhibition of K-ras-NRK cells with IC 50 0.32 μg/mL.

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