Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family
Current Biology, ISSN: 0960-9822, Vol: 8, Issue: 22, Page: 1207-S4
1998
- 161Citations
- 84Captures
- 9Mentions
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations161
- Citation Indexes161
- 161
- CrossRef144
- Captures84
- Readers84
- 84
- Mentions9
- References9
- Wikipedia9
Article Description
The initiation of anaphase and exit from mitosis depend on the activation of the cyclosome/anaphase-promoting complex (APC) that ubiquitinates regulatory proteins such as anaphase inhibitors and mitotic cyclins [1–4]. Genetic experiments have demonstrated that two related WD40-repeat proteins – called Cdc20p and Hct1p/Cdh1p in budding yeast and Fizzy and Fizzy-related in Drosophila – are essential for APC-dependent proteolysis [5–11]. Human orthologs of these proteins – hCDC20/p55 CDC [12] and hCDH1 – have recently been found to associate with APC in a cell-cycle-dependent manner [13,14]. Here, we show that the amount of hCDC20 and hCDH1 bound to APC correlates with a high ubiquitination activity of APC and that binding of recombinant hCDC20 and hCDH1 can activate APC in vitro. Our results suggest that the association between hCDH1 and APC is regulated by post-translational mechanisms, whereas the amount of hCDC20 bound to APC may in addition be controlled by hCDC20 synthesis and destruction [15]. The temporally distinct association of hCDC20 and hCDH1 with APC suggests that these proteins are, respectively, mitosis-specific and G1-specific activating subunits of APC.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0960982207005106; http://dx.doi.org/10.1016/s0960-9822(07)00510-6; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0032488057&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/9811605; https://linkinghub.elsevier.com/retrieve/pii/S0960982207005106; http://linkinghub.elsevier.com/retrieve/pii/S0960982207005106; http://api.elsevier.com/content/article/PII:S0960982207005106?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:S0960982207005106?httpAccept=text/plain; http://dx.doi.org/10.1016/s0960-9822%2807%2900510-6; https://dx.doi.org/10.1016/s0960-9822%2807%2900510-6; http://www.cell.com/article/S0960982207005106/abstract; http://www.cell.com/article/S0960982207005106/fulltext; http://www.cell.com/article/S0960982207005106/pdf; http://www.cell.com/current-biology/abstract/S0960-9822(07)00510-6?_returnURL=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0960982207005106%3Fshowall%3Dtrue
Elsevier BV
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know