Synthesis and biological activities of fluorinated chalcone derivatives
Bioorganic & Medicinal Chemistry, ISSN: 0968-0896, Vol: 10, Issue: 3, Page: 699-706
2002
- 61Citations
- 51Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations61
- Citation Indexes61
- 61
- CrossRef37
- Captures51
- Readers51
- 51
Article Description
We have designed and synthesized new 5-lipoxygenase inhibitors, fluorinated 3,4-dihydroxychalcones, and evaluated their biological activities with respect to antiperoxidation activity and in vitro antitumor activities. All fluorinated chalcones tested showed 5-lipoxygenase inhibition on rat basophilic leukemia-1 (RBL-1) cells and inhibitory action on Fe 3+ -ADP induced NADPH-dependent lipid peroxidation in rat liver microsomes. The potencies were comparable or better to that of the lead 3,4-dihydroxychalcone. 6-Fluoro-3,4-dihydroxy-2′,4′-dimethoxy chalcone ( 7 ) was the most effective compound in the in vitro assay using a human cancer cell line panel (HCC panel) consisting of 39 systems.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0968089601003194; http://dx.doi.org/10.1016/s0968-0896(01)00319-4; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=17044456006&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/11814858; http://linkinghub.elsevier.com/retrieve/pii/S0968089601003194; http://api.elsevier.com/content/article/PII:S0968089601003194?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:S0968089601003194?httpAccept=text/plain; https://linkinghub.elsevier.com/retrieve/pii/S0968089601003194; http://dx.doi.org/10.1016/s0968-0896%2801%2900319-4; https://dx.doi.org/10.1016/s0968-0896%2801%2900319-4
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