Synthesis of heparin-like antithrombotics having perphosphorylated thrombin binding domains
Bioorganic & Medicinal Chemistry, ISSN: 0968-0896, Vol: 7, Issue: 9, Page: 1881-1890
1999
- 17Citations
- 11Captures
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Metrics Details
- Citations17
- Citation Indexes17
- 17
- CrossRef8
- Captures11
- Readers11
- 11
Article Description
The synthesis of three heparin analogues (i.e. compounds VI–VIII Figure 1 Scheme 4(i) DMF, H2O, 1h; (ii) 0.1 M aqueous Na2HPO4 (pH 7.0), 0.05 M NH2OH, 2h (26a→VI, 68%), (26b→VII, 80%), (27→VIII, 51%). ) having perphosphorylated thrombin binding domains (TBDs) is reported. These compounds were tested in vitro for their antithrombin III (ATIII)-mediated anti-Xa and antithrombin activities. Conjugates VI and VIII show a remarkable increase in antithrombin activity compared to the structurally related conjugates with persulfated TBDs (i.e. compounds IV and V ), whereas compound VII displays a diminished activity.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S096808969900139X; http://dx.doi.org/10.1016/s0968-0896(99)00139-x; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0032884766&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/10530936; https://linkinghub.elsevier.com/retrieve/pii/S096808969900139X; http://linkinghub.elsevier.com/retrieve/pii/S096808969900139X; http://api.elsevier.com/content/article/PII:S096808969900139X?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:S096808969900139X?httpAccept=text/plain; http://dx.doi.org/10.1016/s0968-0896%2899%2900139-x; https://dx.doi.org/10.1016/s0968-0896%2899%2900139-x
Elsevier BV
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