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A simple and efficient in vitro method for metabolism studies of radiotracers

Nuclear Medicine and Biology, ISSN: 0969-8051, Vol: 28, Issue: 4, Page: 391-395
2001
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Article Description

In vitro metabolism of acetylcholinesterase inhibitors containing 3-[ 18 F]fluoromethylbenzyl- ([ 18 F] 1 ) and 4-[ 18 F]fluorobenzyl-piperidine moieties ([ 18 F] 2 ) was studied and compared with the in vivo metabolism. Defluorination of the [ 18 F] 1 mainly occurred to generate [ 18 F]fluoride ion both in vitro and in vivo. In contrast, the [ 18 F] 2 was converted into an unknown polar metabolite in both metabolism methods and another metabolite, 4-[ 18 F]fluorobenzoic acid in vitro. These results demonstrated that the in vitro method can be used to predict the in vivo metabolism of both radiotracers.

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