A simple and efficient in vitro method for metabolism studies of radiotracers
Nuclear Medicine and Biology, ISSN: 0969-8051, Vol: 28, Issue: 4, Page: 391-395
2001
- 15Citations
- 4Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations15
- Citation Indexes15
- 15
- CrossRef10
- Captures4
- Readers4
Article Description
In vitro metabolism of acetylcholinesterase inhibitors containing 3-[ 18 F]fluoromethylbenzyl- ([ 18 F] 1 ) and 4-[ 18 F]fluorobenzyl-piperidine moieties ([ 18 F] 2 ) was studied and compared with the in vivo metabolism. Defluorination of the [ 18 F] 1 mainly occurred to generate [ 18 F]fluoride ion both in vitro and in vivo. In contrast, the [ 18 F] 2 was converted into an unknown polar metabolite in both metabolism methods and another metabolite, 4-[ 18 F]fluorobenzoic acid in vitro. These results demonstrated that the in vitro method can be used to predict the in vivo metabolism of both radiotracers.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0969805101002037; http://dx.doi.org/10.1016/s0969-8051(01)00203-7; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0035018171&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/11395311; http://linkinghub.elsevier.com/retrieve/pii/S0969805101002037; http://api.elsevier.com/content/article/PII:S0969805101002037?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:S0969805101002037?httpAccept=text/plain; https://linkinghub.elsevier.com/retrieve/pii/S0969805101002037; http://dx.doi.org/10.1016/s0969-8051%2801%2900203-7; http://www.nucmedbio.com/article/S0969-8051(01)00203-7/abstract
Elsevier BV
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