Neuroprotective effect of sumatriptan, a 5-HT 1D receptor agonist, in focal cerebral ischemia of rat brain
Journal of Stroke and Cerebrovascular Diseases, ISSN: 1052-3057, Vol: 7, Issue: 4, Page: 242-249
1998
- 6Citations
- 21Captures
Metric Options: Counts1 Year3 YearSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations6
- Citation Indexes6
- CrossRef4
- Captures21
- Readers21
- 21
Article Description
The effect of the 5-HT 1D receptor agonist sumatriptan on the volume of ischemic injury was studied in rats subjected to permanent middle cerebral artery (MCA) occlusion. Sumatriptan (2 mg/kg) was administered intravenously 5 minutes after MCA occlusion and the ischemic injury volume was determined 3 hours after MCA occlusion using regional adenosine-5′-triphosphate imaging. In addition, electroencephalographic activity, direct current (DC) potential and cortical blood flow (CBF) was monitored throughout the experiment. In untreated animals, MCA occlusion resulted in a decline in penumbral CBF to 43.3%±7.6% of control, 21 spreadsing depression (SD)-like DC shifts with an average integrated depolarization negativity of 320.2±297.4 (mV×min) and an ATP depletion volume of 61.8±22.9 mm 3 (mean±SD). Three hours after MCA occlusion in sumatriptan-treated animals, penumbral CBF recovered to 63.5%±12.6% of control ( P <.05), only 13 SD-like shifts were detected ( P <.05) with a significantly reduced integrated depolarization negativity of 104.7±98.4 (mV×min) ( P <.05), and the volume of ATP depletion decreased to 16.6±12.3 mm 3 ( P <.01). However, no significant neuroprotective effect was observed for the caudate nucleus (untreated, 19.7±16.5 mm 3 ; treated, 7.9±8.5 mm 3 ). The reduction in the volume of ischemic injury in sumatriptantreated animals is explained by both the improvement of blood flow and the inhibition of SD-like shifts leading to an amelioration of the misrelationship between the depolarization-related energy demand and flow-dependent substrate delivery.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S1052305798800335; http://dx.doi.org/10.1016/s1052-3057(98)80033-5; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33847490710&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/17895091; https://linkinghub.elsevier.com/retrieve/pii/S1052305798800335; http://linkinghub.elsevier.com/retrieve/pii/S1052305798800335; http://api.elsevier.com/content/article/PII:S1052305798800335?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:S1052305798800335?httpAccept=text/plain; http://dx.doi.org/10.1016/s1052-3057%2898%2980033-5; https://dx.doi.org/10.1016/s1052-3057%2898%2980033-5
Elsevier BV
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know