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[5] Epstein-barr viral plasmid vectors and their amplifiable derivatives

Methods in Molecular Genetics, ISSN: 1067-2389, Vol: 7, Issue: C, Page: 65-86
1995
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Article Description

EBV replicates its DNA via two modes: During the latent phase of the EBV life cycle, the virus replicates its DNA as a multicopy plasmid once per cell cycle in S phase (1, 2); during the lytic phase of EBV's life cycle the virus amplifies its DNA 100- to 1000- fold within one or two cell generations (6). These two modes of DNA replication require distinct cis - and trans -acting viral genetic elements, which have been identified and used to construct different vectors that mimic the two modes of the DNA replication of EBV.

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