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Novel transdermal drug delivery system with polyhydroxyalkanoate and starburst polyamidoamine dendrimer

Journal of Bioscience and Bioengineering, ISSN: 1389-1723, Vol: 95, Issue: 5, Page: 541-543
2003
  • 73
    Citations
  • 0
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  • 10
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  • 0
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  • 0
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Metric Options:   Counts1 Year3 Year

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Article Description

In search of an efficient transdermal drug delivery system (TDDS), a polyhydroxyalkanoate (PHA)-based system with a polyamidoamine dendrimer was examined. Tamsulosin was used as the model drug. The dendrimer was found to act as the weak enhancer. By adding the dendrimer, the dendrimer-containing PHA matrix achieved the clinically required amount of tamsulosin permeating through the skin model. This is also the first report of the application of PHA and dendrimer to the TDDS.

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