Marked neuropeptide Y-induced contractions via NPY-Y 1 receptor and its desensitization in rat veins
Vascular Pharmacology, ISSN: 1537-1891, Vol: 39, Issue: 6, Page: 325-333
2002
- 4Citations
- 13Captures
Metric Options: Counts1 Year3 YearSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Article Description
The aim of this study was to investigate neuropeptide Y (NPY)-induced vasoconstrictions in rat blood vessels and which NPY receptor subtype is involved in vasoconstrictions. NPY produced marked contractions in rat common jugular, brachial, portal, femoral and tail veins, and vena cava inferior, whereas it produced little or no contractions in rat common carotid, brachial, femoral and tail arteries, and thoracic and abdominal aortae. The maximal NPY-induced contractions were larger than maximal phenylephrine (PE)-induced contractions in the veins. These NPY-induced contractions were blocked by the Y 1 antagonists, SRL-21, and BIBP3226 but not by the Y 5 antagonist, L-152804. A Y 2 agonist, NPY (13–36), did not produce contractions. RT-PCR showed that NPY-Y 1 was the only receptor subtype in the veins indicating that NPY-induced contractions are mediated through the Y 1 receptor. Pretreatment with NPY showed a rapid and long-lasting desensitization of these contractions. The marked NPY-induced contractions and its desensitization in the veins suggest the physiological relevance of NPY in the venous circulation.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S1537189103000442; http://dx.doi.org/10.1016/s1537-1891(03)00044-2; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0038309878&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/14567071; https://linkinghub.elsevier.com/retrieve/pii/S1537189103000442; http://linkinghub.elsevier.com/retrieve/pii/S1537189103000442; http://api.elsevier.com/content/article/PII:S1537189103000442?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:S1537189103000442?httpAccept=text/plain; http://dx.doi.org/10.1016/s1537-1891%2803%2900044-2; https://dx.doi.org/10.1016/s1537-1891%2803%2900044-2
Elsevier BV
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know