Extracorporeal Photopheresis in Dermatology
Actas Dermo-Sifiliográficas (English Edition), ISSN: 1578-2190, Vol: 100, Issue: 6, Page: 459-471
2009
- 1Citations
- 9Captures
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Metrics Details
- Citations1
- Citation Indexes1
- CrossRef1
- Captures9
- Readers9
Article Description
Extracorporeal photochemotherapy or photopheresis is an immunomodulatory therapy that combines leukapheresis with phototherapy. Blood from the patient is processed to give a leukocyte-rich plasma, which is then treated ex vivo with a photosensitizer and ultraviolet A radiation before reinfusion back into the patient. The exact mechanism of action of photopheresis has not been fully elucidated although it is thought that induction of leukocyte apoptosis and formation of dendritic cells is essential for the development of an immune response to pathogenic cells. Extracorporeal photopheresis was initially used for treating cutaneous T-cell lymphoma. Since then, in view of its efficacy and safety, it has been used in a number of cutaneous and non cutaneous diseases with uneven results, which can in part be explained by the different patient selection criteria, therapy regimens, and follow-up protocols used in different hospitals. La fotoquimioterapia extracorpórea o fotoféresis es una terapia inmunomoduladora que combina la leucoféresis con la fototerapia. Después de la separación de un plasma rico en leucocitos, se administra ex vivo un fotosensibilizante junto con radiación ultravioleta A y posteriormente se reinfunde en el paciente. El mecanismo de acción exacto de la fotoféresis no se conoce completamente, aunque se piensa que la inducción de apoptosis de linfocitos y la formación de células dendríticas desempeña un papel fundamental en el desarrollo de una respuesta inmunológica contra las células patógenas. Esta terapia se utilizó inicialmente para el tratamiento del linfoma cutáneo de células T. Desde entonces, basándose en su eficacia y seguridad, se ha empleado en múltiples patologías tanto cutáneas como no cutáneas, con resultados variables. Los distintos centros han utilizado diferentes criterios de selección de pacientes, pautas de tratamiento y protocolos de monitorización, lo que podría contribuir a la diferencia de resultados.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S1578219009701027; http://dx.doi.org/10.1016/s1578-2190(09)70102-7; https://linkinghub.elsevier.com/retrieve/pii/S1578219009701027; http://linkinghub.elsevier.com/retrieve/pii/S1578219009701027; http://api.elsevier.com/content/article/PII:S1578219009701027?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:S1578219009701027?httpAccept=text/plain; http://dx.doi.org/10.1016/s1578-2190%2809%2970102-7; https://dx.doi.org/10.1016/s1578-2190%2809%2970102-7
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