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The HIV cure research agenda: the role of mathematical modelling and cost-effectiveness analysis

Journal of Virus Eradication, ISSN: 2055-6640, Vol: 1, Issue: 4, Page: 245-249
2015
  • 11
    Citations
  • 0
    Usage
  • 32
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    11
    • Citation Indexes
      11
      • CrossRef
        11
  • Captures
    32

Review Description

The research agenda towards an HIV cure is building rapidly. In this article, we discuss the reasons for and methodological approach to using mathematical modelling and cost-effectiveness analysis in this agenda. We provide a brief description of the proof of concept for cure and the current directions of cure research. We then review the types of clinical economic evaluations, including cost analysis, cost-benefit analysis and cost-effectiveness analysis. We describe the use of mathematical modelling and cost-effectiveness analysis early in the HIV epidemic as well as in the era of combination antiretroviral therapy. We then highlight the novel methodology of Value of Information (VOI) analysis and its potential role in the planning of clinical trials. We close with recommendations for modelling and cost-effectiveness analysis in the HIV cure agenda.

Bibliographic Details

Kenneth A. Freedberg; Cristina Possas; Steven Deeks; AnnaLaura Ross; Katherine L. Rosettie; Michele Di Mascio; Chris Collins; Rochelle P. Walensky; Yazdan Yazdanpanah

Elsevier BV

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