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Effects of grape seed extract beverage on blood pressure and metabolic indices in individuals with pre-hypertension: A randomised, double-blinded, two-arm, parallel, placebo-controlled trial

British Journal of Nutrition, ISSN: 1475-2662, Vol: 115, Issue: 2, Page: 226-238
2016
  • 83
    Citations
  • 0
    Usage
  • 187
    Captures
  • 4
    Mentions
  • 27
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    83
  • Captures
    187
  • Mentions
    4
    • News Mentions
      3
      • 3
    • Blog Mentions
      1
      • Blog
        1
  • Social Media
    27
    • Shares, Likes & Comments
      27
      • Facebook
        27

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Grape Seed Extract: A Health-Boosting Secret Found in Grapes

Reprinted with the kind permission of Dr. Mercola . Grapes are one of the most popular fruits in the U.S. In 2016 alone, statistics indicate

Article Description

The aim of the present study was to test grape seed extract (GSE) as a functional ingredient to lower blood pressure (BP) in individuals with pre-hypertension. A single-centre, randomised, two-arm, double-blinded, placebo-controlled, 12-week, parallel study was conducted in middle-aged adults with pre-hypertension. A total of thirty-six subjects were randomised (1:1) to Placebo (n 18) or GSE (n 18) groups; twenty-nine of them completed all the protocol-specified procedures (Placebo, n 17; GSE, n 12). Subjects consumed a juice (167 kJ (40 kcal)) containing 0 mg (Placebo) or 300 mg/d GSE (150 mg) twice daily for 6 weeks preceded by a 2-week Placebo run-in and followed by 4-week no-beverage follow-up. Compliance was monitored. BP was measured at screening, 0, 6 and 10 weeks of intervention and blood samples were collected at 0, 3, 6 and 10 weeks of intervention. GSE significantly reduced systolic BP (SBP) by 5·6 % (P=0·012) and diastolic BP (DBP) by 4·7 % (P=0·049) after 6 weeks of intervention period, which was significantly different (SBP; P=0·03) or tended to be different (DBP; P=0·08) from Placebo. BP returned to baseline after the 4-week discontinuation period of GSE beverage. Subjects with higher initial BP experienced greater BP reduction; nearly double the effect size. Fasting insulin and insulin sensitivity tended to improve after 6 weeks of GSE beverage supplementation (P=0·09 and 0·07, respectively); no significant changes were observed with fasting plasma lipids, glucose, oxidised LDL, flow-mediated dilation or vascular adhesion molecules. Total plasma phenolic acid concentrations were 1·6 times higher after 6 weeks of GSE v. Placebo. GSE was found to be safe and to improve BP in people with pre-hypertension, supporting the use of GSE as a functional ingredient in a low-energy beverage for BP control.

Bibliographic Details

http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84951561612&origin=inward; http://dx.doi.org/10.1017/s0007114515004328; http://www.ncbi.nlm.nih.gov/pubmed/26568249; http://www.journals.cambridge.org/abstract_S0007114515004328; https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0007114515004328; https://www.cambridge.org/core/product/identifier/S0007114515004328/type/journal_article; https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/div-classtitleeffects-of-grape-seed-extract-beverage-on-blood-pressure-and-metabolic-indices-in-individuals-with-pre-hypertension-a-randomised-double-blinded-two-arm-parallel-placebo-controlled-trialdiv/5F6691274A6C0D4D15E934F2403296E9; https://www.cambridge.org/core/services/aop-cambridge-core/content/view/5F6691274A6C0D4D15E934F2403296E9/S0007114515004328a.pdf/div-class-title-effects-of-grape-seed-extract-beverage-on-blood-pressure-and-metabolic-indices-in-individuals-with-pre-hypertension-a-randomised-double-blinded-two-arm-parallel-placebo-controlled-trial-div.pdf; http://journals.cambridge.org/abstract_S0007114515004328; https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/effects-of-grape-seed-extract-beverage-on-blood-pressure-and-metabolic-indices-in-individuals-with-prehypertension-a-randomised-doubleblinded-twoarm-parallel-placebocontrolled-trial/5F6691274A6C0D4D15E934F2403296E9; http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=10071082&fulltextType=RA&fileId=S0007114515004328; https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/effects-of-grape-seed-extract-beverage-on-blood-pressure-and-metabolic-indices-in-individuals-with-pre-hypertension-a-randomised-double-blinded-two-arm-parallel-placebo-controlled-trial/5F6691274A6C0D4D15E934F2403296E9; http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=10071082&fulltextType=RA&fileId=S0007114515004328; http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=10071082&fileId=S0007114515004328

Park, Eunyoung; Edirisinghe, Indika; Choy, Ying Yng; Waterhouse, Andrew; Burton-Freeman, Britt

Cambridge University Press (CUP)

Medicine; Nursing

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