Effects of grape seed extract beverage on blood pressure and metabolic indices in individuals with pre-hypertension: A randomised, double-blinded, two-arm, parallel, placebo-controlled trial
British Journal of Nutrition, ISSN: 1475-2662, Vol: 115, Issue: 2, Page: 226-238
2016
- 83Citations
- 187Captures
- 4Mentions
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Metrics Details
- Citations83
- Citation Indexes82
- 82
- CrossRef61
- Policy Citations1
- 1
- Captures187
- Readers187
- 187
- Mentions4
- News Mentions3
- 3
- Blog Mentions1
- Blog1
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Grape Seed Extract: A Health-Boosting Secret Found in Grapes
Reprinted with the kind permission of Dr. Mercola . Grapes are one of the most popular fruits in the U.S. In 2016 alone, statistics indicate
Article Description
The aim of the present study was to test grape seed extract (GSE) as a functional ingredient to lower blood pressure (BP) in individuals with pre-hypertension. A single-centre, randomised, two-arm, double-blinded, placebo-controlled, 12-week, parallel study was conducted in middle-aged adults with pre-hypertension. A total of thirty-six subjects were randomised (1:1) to Placebo (n 18) or GSE (n 18) groups; twenty-nine of them completed all the protocol-specified procedures (Placebo, n 17; GSE, n 12). Subjects consumed a juice (167 kJ (40 kcal)) containing 0 mg (Placebo) or 300 mg/d GSE (150 mg) twice daily for 6 weeks preceded by a 2-week Placebo run-in and followed by 4-week no-beverage follow-up. Compliance was monitored. BP was measured at screening, 0, 6 and 10 weeks of intervention and blood samples were collected at 0, 3, 6 and 10 weeks of intervention. GSE significantly reduced systolic BP (SBP) by 5·6 % (P=0·012) and diastolic BP (DBP) by 4·7 % (P=0·049) after 6 weeks of intervention period, which was significantly different (SBP; P=0·03) or tended to be different (DBP; P=0·08) from Placebo. BP returned to baseline after the 4-week discontinuation period of GSE beverage. Subjects with higher initial BP experienced greater BP reduction; nearly double the effect size. Fasting insulin and insulin sensitivity tended to improve after 6 weeks of GSE beverage supplementation (P=0·09 and 0·07, respectively); no significant changes were observed with fasting plasma lipids, glucose, oxidised LDL, flow-mediated dilation or vascular adhesion molecules. Total plasma phenolic acid concentrations were 1·6 times higher after 6 weeks of GSE v. Placebo. GSE was found to be safe and to improve BP in people with pre-hypertension, supporting the use of GSE as a functional ingredient in a low-energy beverage for BP control.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84951561612&origin=inward; http://dx.doi.org/10.1017/s0007114515004328; http://www.ncbi.nlm.nih.gov/pubmed/26568249; http://www.journals.cambridge.org/abstract_S0007114515004328; https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0007114515004328; https://www.cambridge.org/core/product/identifier/S0007114515004328/type/journal_article; https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/div-classtitleeffects-of-grape-seed-extract-beverage-on-blood-pressure-and-metabolic-indices-in-individuals-with-pre-hypertension-a-randomised-double-blinded-two-arm-parallel-placebo-controlled-trialdiv/5F6691274A6C0D4D15E934F2403296E9; https://www.cambridge.org/core/services/aop-cambridge-core/content/view/5F6691274A6C0D4D15E934F2403296E9/S0007114515004328a.pdf/div-class-title-effects-of-grape-seed-extract-beverage-on-blood-pressure-and-metabolic-indices-in-individuals-with-pre-hypertension-a-randomised-double-blinded-two-arm-parallel-placebo-controlled-trial-div.pdf; http://journals.cambridge.org/abstract_S0007114515004328; https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/effects-of-grape-seed-extract-beverage-on-blood-pressure-and-metabolic-indices-in-individuals-with-prehypertension-a-randomised-doubleblinded-twoarm-parallel-placebocontrolled-trial/5F6691274A6C0D4D15E934F2403296E9; http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=10071082&fulltextType=RA&fileId=S0007114515004328; https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/effects-of-grape-seed-extract-beverage-on-blood-pressure-and-metabolic-indices-in-individuals-with-pre-hypertension-a-randomised-double-blinded-two-arm-parallel-placebo-controlled-trial/5F6691274A6C0D4D15E934F2403296E9; http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=10071082&fulltextType=RA&fileId=S0007114515004328; http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=10071082&fileId=S0007114515004328
Cambridge University Press (CUP)
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