Biphasic effects of Δ-tetrahydrocannabinol on brain stimulation reward and motor activity
International Journal of Neuropsychopharmacology, ISSN: 1461-1457, Vol: 16, Issue: 10, Page: 2273-2284
2013
- 79Citations
- 93Captures
- 2Mentions
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations79
- Citation Indexes77
- 77
- CrossRef42
- Policy Citations2
- Policy Citation2
- Captures93
- Readers93
- 93
- Mentions2
- Blog Mentions2
- Blog2
Conference Paper Description
Abstract Δ-tetrahydrocannabinol (Δ-THC) , the main psychoactive ingredient of marijuana, has led to equivocal results when tested with the intracranial self-stimulation (ICSS) procedure or the open-field test for motor activity, two behavioural models for evaluating the reward-facilitating and locomotor stimulating effects of drugs of abuse, respectively. Therefore, in the present study, the effects of high and low doses of Δ-THC were compared in the ICSS procedure and the open-field test. Moreover, the involvement of CB1 receptors in tentative Δ-THC-induced effects was investigated by pre-treating the animals with the CB1 receptor antagonist SR141716A (rimonabant). The results obtained show that low doses of Δ-THC induce opposite effects from high doses of Δ-THC. Specifically, 0.1 mg/kg Δ-THC decreased ICSS thresholds and produced hyperactivity, whereas 1 mg/kg increased ICSS thresholds and produced hypoactivity. Both effects were reversed by pre-treatment with SR141716A, indicating the involvement of CB1 receptors on these actions. Altogether, our results indicate that Δ-THC can produce acute activating effects in locomotion that coincide with its reward-facilitating effects in the ICSS paradigm. The present findings provide further support that Δ-THC induces behaviours typical of abuse and substantiate the notion that marijuana resembles other drugs of abuse. © CINP 2013.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84885575637&origin=inward; http://dx.doi.org/10.1017/s1461145713000709; http://www.ncbi.nlm.nih.gov/pubmed/23830148; https://academic.oup.com/ijnp/article-lookup/doi/10.1017/S1461145713000709; http://academic.oup.com/ijnp/article-pdf/16/10/2273/1844170/16-10-2273.pdf; https://academic.oup.com/ijnp/article/16/10/2273/653108
Oxford University Press (OUP)
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