Programmed regulation of rat offspring adipogenic transcription factor (PPARγ) by maternal nutrition
Journal of Developmental Origins of Health and Disease, ISSN: 2040-1752, Vol: 6, Issue: 6, Page: 530-538
2015
- 19Citations
- 27Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations19
- Citation Indexes17
- 17
- CrossRef15
- Policy Citations2
- Policy Citation2
- Captures27
- Readers27
- 27
Article Description
We determined the protein expression of adipogenic transcription factor, peroxisome proliferator-activated receptor gamma (PPARγ) and its co-repressor and co-activator complexes in adipose tissue from the obese offspring of under- and over-nourished dams. Female rats were fed either a high-fat (60% kcal) or control (10% kcal) diet before mating, and throughout pregnancy and lactation (Mat-OB). Additional dams were 50% food-restricted from pregnancy day 10 to term [intrauterine growth-restricted (IUGR)]. Adipose tissue protein expression was analyzed in newborn and adult male offspring. Normal birth weight Mat-OB and low birth weight IUGR newborns had upregulated PPARγ with variable changes in co-repressors and co-activators. As obese adults, Mat-OB and IUGR offspring had increased PPARγ with decreased co-repressor and increased co-activator expression. Nutritionally programmed increased PPARγ expression is associated with altered expression of its co-regulators in the newborn and adult offspring. Functional studies of PPARγ co-regulators are necessary to establish their role in PPARγ-mediated programmed obesity.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84945448991&origin=inward; http://dx.doi.org/10.1017/s2040174415001440; http://www.ncbi.nlm.nih.gov/pubmed/26286138; https://www.cambridge.org/core/product/identifier/S2040174415001440/type/journal_article; http://www.journals.cambridge.org/abstract_S2040174415001440; https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S2040174415001440; https://www.cambridge.org/core/journals/journal-of-developmental-origins-of-health-and-disease/article/div-classtitleprogrammed-regulation-of-rat-offspring-adipogenic-transcription-factor-ppar-by-maternal-nutritiona-hreffn1-ref-typefnadiv/E666DACFCA1F8AA880EF5719ECF010D5
Cambridge University Press (CUP)
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