Dithiol Aryl Arsenic Compounds as Potential Diagnostic and Therapeutic Radiopharmaceuticals
Inorganic Chemistry, ISSN: 1520-510X, Vol: 55, Issue: 16, Page: 8091-8098
2016
- 23Citations
- 34Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations23
- Citation Indexes23
- CrossRef23
- 23
- Captures34
- Readers34
- 34
Article Description
Arsenic-72 (As) and As have nuclear properties useful for positron emission tomography (PET) and radiotherapy, respectively. The thiophilic nature of arsenic led to the evaluation of dithioarylarsines for potential use in radiopharmaceuticals. Several dithioarylarsines were synthesized from their arylarsonic acids and dithiols and were fully characterized by NMR, ESI-MS, and X-ray crystallography. This chemistry was translated to the no-carrier-added (nca) As level. Because arsenic was available at the nca nanomolar level only as [As]arsenate, this required addition of an aryl group directly to the As to form the [As]arylarsonic acid. The [As]arsenate was reduced from As (V) to As (III), and a modified Bart reaction was used to incorporate the aryl ring onto the As, which was followed by dithiol addition. Various modifications and optimizations resulted in 95% radiochemical yield of nca [As]p-ethoxyphenyl-1,2-ethanedithiolatoarsine.
Bibliographic Details
American Chemical Society (ACS)
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