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Transition-Metal-Free Synthesis of Ynones via Decarboxylative Alkynylation of α-Keto Acids under Mild Conditions

Journal of Organic Chemistry, ISSN: 1520-6904, Vol: 80, Issue: 18, Page: 9314-9320
2015
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Article Description

A transition-metal-free synthetic method of various ynones via decarboxylative alkynylation of α-keto acids is described. The reaction is carried out under mild conditions and exhibits remarkable tolerance of functional groups. The mechanism of a radical process is proposed in the reaction.

Bibliographic Details

Wang, Peng-Fei; Feng, Yi-Si; Cheng, Zhi-Fei; Wu, Qiu-Min; Wang, Guang-Yu; Liu, Liang-Liang; Dai, Jian-Jun; Xu, Jun; Xu, Hua-Jian

American Chemical Society (ACS)

Chemistry

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