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Gambierone, a Ladder-Shaped Polyether from the Dinoflagellate Gambierdiscus belizeanus

Organic Letters, ISSN: 1523-7052, Vol: 17, Issue: 10, Page: 2392-2395
2015
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Article Description

A new natural product named gambierone (1) was isolated from the cultured dinoflagellate Gambierdiscus belizeanus. The structure of this compound features an unprecedented polyether skeleton and an unusual right-hand side chain. Its relative configuration was fully determined by interpretation of ROESY experiment and comparison between experimental and theoretical NMR data. Although the succession of cycles has no chemical similarity with ciguatoxins, 1 has a molecular formula and biological activity similar to those of CTX-3C, although much lower in intensity.

Bibliographic Details

Rodríguez, Inés; Genta-Jouve, Grégory; Alfonso, Carmen; Calabro, Kevin; Alonso, Eva; Sánchez, Jon A; Alfonso, Amparo; Thomas, Olivier P; Botana, Luis M

American Chemical Society (ACS)

Biochemistry, Genetics and Molecular Biology; Chemistry

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