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Tumor-Responsive Upconversion Nanoparticles with Tunable Degradability and Ultrabright Emission for Optical Bioimaging

ACS Applied Nano Materials, ISSN: 2574-0970, Vol: 5, Issue: 7, Page: 9367-9378
2022
  • 14
    Citations
  • 0
    Usage
  • 8
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    14
    • Citation Indexes
      14
  • Captures
    8

Article Description

Rare earth (RE)-based inorganic upconversion nanoparticles (UCNPs) have huge potency for applications varying from bioimaging to theranostics of tumors. For these applications, it is of great importance that UCNPs be expelled innocuously from a living body during a rational period of time after executing their diagnostic and/or therapeutic tasks. Despite great efforts to modulate biodegradability, a reasonable biodegradation rate for currently available UCNPs in weakly alkaline physiochemical buffers has not yet been realized. Herein, to achieve a tunable biodegradation rate for UCNPs, a class of core-shell-structured nanoparticles is invented by heteroepitaxially growing a CaF:Yb shell with varying Zrdoping content on a biodegradable NaZrF:Yb,Er core. The CaF:Yb,Zr shell can not only enhance the emission intensity but also ensure the overall biodegradation of the nanocrystals. The degradation rate of core-shell UCNPs can be easily modulated by changing the Zrdoping content in the shell, and the degradation rate is pH-responsive; thus, tumor acidity-triggered degradation can be realized. When sodium alginate (SA)-modified UCNPs are used for the bioimaging of tumors, the intracellularly degraded metal ions and the released SA molecules can self-assemble through a coordination cross-linking effect, thereby improving the tumor retention of the nanosystems. These discoveries will unequivocally promote the future clinical applications of RE-based UCNPs.

Bibliographic Details

Wubin Lv; Jin Ye; Qiang Wang; Chunsheng Li; Jun Wang; Zhiyong Zhang; Na Niu; Zhiguo Liu; Jiating Xu; Yujie Fu

American Chemical Society (ACS)

Materials Science

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