The Catalytic Mechanism of DNA and RNA Polymerases
ACS Catalysis, ISSN: 2155-5435, Vol: 8, Issue: 12, Page: 11103-11118
2018
- 25Citations
- 65Captures
Metric Options: Counts1 Year3 YearSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Article Description
DNA and RNA polymerases (Pols) catalyze nucleic acid biosynthesis in all domains of life, with implications for human diseases and health. Pols carry out nucleic acid extension through the addition of one incoming nucleotide trisphosphate at the 3′-OH terminus of the growing primer strand, at every catalytic cycle. Thus, Pol catalysis involves chemical reactions for nucleophile 3′-OH deprotonation and nucleotide addition, as well as major protein conformational motions and structural rearrangements for nucleotide selection, binding, and nucleic acid translocation to complete the overall catalytic cycle. In this respect, quantum and molecular mechanics simulations, integrated with experimental data, have advanced our mechanistic understanding of how Pols operate at the atomic level. This Perspective outlines how modern molecular simulations can further deepen our understanding of Pol catalytic reactions and fidelity, which may help in devising strategies for designing drugs and artificial Pols for biotechnological and clinical purposes.
Bibliographic Details
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know