1-acetylpyrene-salicylic acid: Photoresponsive fluorescent organic nanoparticles for the regulated release of a natural antimicrobial compound, salicylic acid
ACS Applied Materials and Interfaces, ISSN: 1944-8252, Vol: 6, Issue: 10, Page: 7045-7054
2014
- 32Citations
- 26Captures
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Metrics Details
- Citations32
- Citation Indexes32
- 32
- CrossRef31
- Captures26
- Readers26
- 26
Article Description
Photoresponsive 1-acetylpyrene-salicylic acid (AcPy-SA) nanoparticles (NPs) were developed for the regulated release of a natural antimicrobial compound, salicylic acid. The strong fluorescent properties of AcPy-SA NPs have been extensively used for potential in vitro cell imaging. The phototrigger capability of our newly prepared AcPy-SA NPs was utilized for the efficient release of an antimicrobial compound, salicylic acid. The photoregulated drug release of AcPy-SA NPs has been shown by the subsequent switching off and on of a visible-light source. In vitro biological studies reveal that AcPy-SA NPs of ∼68 nm size deliver the antimicrobial drug salicylic acid into the bacteria cells (Pseudomonas aeruginosa) and efficiently kill the cells upon exposure to visible light (≥410 nm). Such photoresponsive fluorescent organic NPs will be highly beneficial for targeted and regulated antimicrobial drug release because of their biocompatible nature, efficient cellular uptake, and light-induced drug release ability. © 2014 American Chemical Society.
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