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Autophagy and neurodegeneration.

ACS chemical biology, ISSN: 1554-8937, Vol: 1, Issue: 4, Page: 211-213
2006
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Review Description

Autophagy mediates the bulk degradation of cytosolic proteins and organelles. Recent studies using neuron-specific knockout mouse models demonstrate that autophagy deficiency leads to protein aggregation and neurodegeneration, even in the absence of disease-related aggregate-prone proteins.

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