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Immobilized N-chlorosuccinimide as a friendly peptide disulfide-forming reagent

ACS Combinatorial Science, ISSN: 2156-8952, Vol: 16, Issue: 4, Page: 160-163
2014
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Article Description

A novel immobilized N-chlorosuccinimide resin was developed for peptide disulfide bond formation in combinatorial libraries. The resin is prepared in a simple two-step process from commercial starting materials. Disulfide formation is initiated by adding a peptide solution to the resin, and excess reagent is removed by a convenient filtration upon completion of disulfide formation. Completion of disulfide formation is rapid and clean, as demonstrated by the oxidation of a small nonapeptide library. This immobilized reagent allows a wider scope for the use of N-chlorosuccinimide-based disulfide formation in combinatorial chemistry. © 2014 American Chemical Society.

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