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Zinc-Nucleic Acid Interaction

Chemical Reviews, ISSN: 0009-2665, Vol: 104, Issue: 2, Page: 769-787
2004
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Article Description

A variety of derivatives of Zn-cyclen complexes have been designed as prototypes of selective receptors of 'imide'- containing nucleobases, thymine (dT) and uracil (U), in aqueous solution at physiological pH. The Zn-cyclen complexes with polyaromatic pendants possess recognition efficiency in terms of K on the order of 10 μM in single- and double-stranded DNA (or RNA) to disrupt A-dT hydrogen bonds in double-stranded nucleic acids. A direct correlation was found between the binding of Tat to TAR RNA and up-regulation of HIV-1 mRNA transcription. The potent inhibition of HIV-1 TAR RNA-Tat peptide binding by Zn complexes was described.

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