Electrochemistry of nonconjugated proteins and glycoproteins. Toward sensors for biomedicine and glycomics
Chemical Reviews, ISSN: 1520-6890, Vol: 115, Issue: 5, Page: 2045-2108
2015
- 303Citations
- 305Captures
- 1Mentions
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Metrics Details
- Citations303
- Citation Indexes303
- 303
- CrossRef273
- Captures305
- Readers305
- 305
- Mentions1
- References1
- Wikipedia1
Review Description
Significant progress has been done in the electrochemical (EC) analysis of practically all proteins, based on the electroactivity of amino acid (aa) residues in proteins. From a transducer point of view, it can be anticipated that many different ways of how nanomaterials can be integrated into the EC detection platform of detection will be developed. This can be done by direct modification of electroactive surfaces by nanomaterials or by advanced patterning protocol and by using nanomaterials as amplification tags, helping to produce lectin biosensors/biochips working in an ultrasensitive and selective way. Further, it can be anticipated that EC-based biosensors will compete in a future with instrumental techniques or lectin microarrays only if such devices are integrated into a biochip format offering multiplexed glycan measurements. Moreover, it has been shown that some glucosamine-containing poly- and oligosaccharides are electroactive under conditions close to physiological and that most polysaccharides and glycans can be transformed into electrochemically active substances by a simple chemical modification. Usually 4-10 biomarkers have to be detected to obtain good specificity and selectivity of detection. EC detection appears particularly advantageous for the preparation of low-density chips with this number of biomarkers.
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