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trans-platinum planar amine compounds with [NO] ligand donor sets: Effects of carboxylate leaving groups and steric hindrance on chemical and biological properties

Inorganic Chemistry, ISSN: 0020-1669, Vol: 45, Issue: 15, Page: 5733-5735
2006
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Article Description

Replacement of NH by a planar amine L to give trans-[PtCl (L)-(L′)] (L = NH, L′= pyridine or substituted pyridine, quinoline, isoquinoline, thiazole; L = L′= pyridine, thiazole), greatly enhances the cytotoxicity of the transplatinum geometry. The "parent" compound trans-[PtCl(NH) ] is therapeutically inactive. Modification of the ligands to an [NO] donor set, where O represents an acetate leaving group, enhances the aqueous solubility while retaining the cytotoxicity of the parent chloride compounds. The effect of two mutual trans leaving groups with weak trans influence is to impart remarkable chemical stability on the structure. This strategy is analogous to the use of the inert dicarboxylate leaving groups in the clinical compounds carboplatin and oxaliplatin. In this paper, systematic modification of the steric effects of carrier pyridine groups and, especially, carboxylate leaving groups in trans-[Pt(OCR) (NH)(pyr)] is shown to modulate aqueous solubility and hydrolysis to the activated aqua species. The results presented here demonstrate the utility of the "carboxylate strategy" in "fine-tuning" the chemical and pharmacokinetic properties in the design of clinically relevant transplatinum complexes. © 2006 American Chemical Society.

Bibliographic Details

Bulluss, Genevieve H; Knott, Kenneth M; Ma, Erin S F; Aris, Sheena M; Alvarado, Eugenio; Farrell, Nicholas

American Chemical Society (ACS)

Chemistry

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